Prostate Specific Antigen (PSA)

Prostate-specific Antigen (PSA) CPT: 84153

Synonyms

PSA, Serum

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Expected Turnaround Time

Within 1 day

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Specimen Requirements

Specimen

Serum

Volume

0.8 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection

If a red-top tube is used, transfer separated serum to a plastic transport tube.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature	Period
Room Temperature	Not recommended
Refrigerated	7 days
Frozen	4 weeks
Freeze/thaw/ cycles	Stable x 3

Patient Information

Why Get Tested?

To screen men for prostate cancer, to help determine the necessity for a biopsy of the prostate, to monitor the effectiveness of treatment for prostate cancer, and/or to detect recurrence of prostate cancer.

When To Get Tested?

When a man has symptoms suggestive of prostate cancer such as difficult, painful, and/or frequent urination; may also be ordered during and at regular intervals after prostate cancer treatment; in asymptomatic men, after a discussion with your healthcare provider about the benefits and harms of screening and you make an informed decision to undergo screening (For specific details, see prostate cancer screening for Adults and Adults 50 and Up).

Sample Required?

A blood sample drawn from a vein in your arm.

Test Preparation Needed?

Avoid ejaculation for 24 hours before sample collection as it has been associated with elevated PSA levels; the sample should also be collected prior to your health practitioner performing a digital rectal exam (DRE) and prior to (or several weeks after) a prostate biopsy.