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Vitamin B12 CPT: 82607

Special Instructions

This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

Expected Turnaround Time

Within 1 day

Specimen Requirements

Specimen

Serum

Volume

0.8 mL

Minimum Volume

0.3 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube.

Collection

If a red-top tube is used, transfer separated serum to a plastic transport tube.

Storage Instructions

Room temperature

Stability Requirements

Temperature Period
Room Temperature 7 day
Refrigerated 7 days
Frozen 14 days
Freeze/thaw/ cycles Stable x 3

Patient Information

To help diagnose one cause of anemia or neuropathy; to evaluate nutritional status in some people; to monitor the effectiveness of treatment for vitamin B12 or folate deficiency.

When you have abnormal results on a complete blood count (CBC) with a blood smear showing large red blood cells (macrocytosis) or abnormal (hypersegmented) neutrophils; when you have symptoms of anemia (weakness, tiredness, pale skin) and/or of neuropathy (tingling or itching sensations, eye twitching, memory loss, altered mental status); when you are being treated for vitamin B12 or folate deficiency.

A blood sample drawn from a vein in your arm.

Biotin found in certain dietary supplements may interfere with testing. Certain medicines, such as cholchicine, neomycin, para-aminosalicylic acid, and phenytoin, may affect the test results; your healthcare provider will advise you on which ones to stop taking. Ask your healthcare practitioner or lab for specific instructions.